FDA Submission Expected This Summer - Invest Before It Happens

This company is making heart disease easier to detect with AI. Their tech has officially been designated a "Breakthrough" by the FDA. You now have an opportunity to get in at a potential inflection point.

Microsoft's $4 Trillion Moment Could Supercharge ETF Strategies

Chandrima Sanyal
August 02, 2025

As Microsoft (NASDAQ:MSFT) flirts with the $4 trillion market cap, ETFs exposed to the stock have found themselves in the limelight. Underneath the surface of earnings beats and valuation records is a larger narrative: Microsoft has become the infrastructure layer of the AI revolution.

Microsoft’s Q4 blockbuster earings were stuff from the market lore, Azure cloud revenue jumped 39%, Office and Copilot adoption flew, and the company beat on EPS and revenue. That’s the sheen on top.

But dig deeper and you'll see what the market is beginning to whisper: Microsoft has become the utility company of AI. Its $30 billion+ quarterly capex is pouring directly into data center buildouts, custom chips, and AI-integrated cloud services--an aggressive strategy that positions Microsoft as the backend for everything from ChatGPT to enterprise AI rollouts.

This transformation means that owning Microsoft-heavy ETFs is an exposure to the infrastructure play behind generative AI's explosive growth.

Also Read: Bond ETFs Could Catch A Tailwind From Jobs Data

The ETF Angle: Funds That Stand To Benefit From Microsoft's AI Ascent

Here's where the plot thickens. Investors looking to surf the Microsoft-AI wave without stock-picking risk are increasingly turning to thematic and tech-focused ETFs with deep Microsoft allocations.

Among them are:

Global X Artificial Intelligence & Technology ETF (NASDAQ:AIQ): Highly skewed toward leaders in the cloud/AI space, including Microsoft. AIQ is really a packaged play on the enterprise AI arms race.

iShares Expanded Tech-Software Sector ETF (BATS:IGV): One of the top three holdings is Microsoft. IGV’s decent year-to-date performance is quietly powered by Microsoft’s Copilot and Azure monetization narrative.

Vanguard Information Technology ETF (NYSE:VGT) and Technology Select Sector SPDR Fund (NYSE:XLK): These large-cap tech ETFs have MSFT among its top holdings, directly profiting from its size and profitability.

Basically, these funds are riding Microsoft’s “cloud plus chips” AI plan quietly and are not yelling it from the roof tops. The investors who get that MSFT is not merely selling software but constructing the digital scaffolding of the world of AI are most likely to gain.

The Bottom Line: ETFs As AI Infrastructure Proxies

Microsoft’s rise to $4 trillion will not only be a milestone, it’s an indicator. It’s no longer merely a software giant; it’s an essential part of the AI hardware-software stack. While the demand for compute power, enterprise integration, and cloud-based AI takes off, Microsoft’s scale emerges as the new moat.

And ETFs that position in this shift, intentionally or unintentionally, could be some of the brightest bets for long-term access to the AI economy’s infrastructure layer.

In a world rushing after trendy AI startups, these ETFs could be holding the picks and shovels.

Read Next:

  • Eurozone GDP Growth Pops A Surprise: These ETFs Are Winning The Game

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