No.1 Opportunity for 2025 [Take Action Now!]

Starlink's potential IPO Could Be the Biggest in History--Silicon Valley insider James Altucher has uncovered a way to profit BEFORE the IPO--with as little as $50. Musk's $180B giant is set to launch--will you miss out? Claim your spot before it's too late.

Eventful Monday For AstraZeneca - What's Going On?

Vandana Singh
March 17, 2025

On Monday, AstraZeneca Plc (NASDAQ:AZN) released high-level results from the CALYPSO Phase 3 trial designed to evaluate the efficacy and safety of eneboparatide in adults with chronic hypoparathyroidism.

The study showed that eneboparatide (AZP-3601), an investigational parathyroid hormone (PTH) receptor 1 agonist, met its primary endpoint with statistical significance at 24 weeks in adults with chronic hypoparathyroidism (HypoPT) compared to placebo.

The primary endpoint is a composite of normalization of albumin-adjusted serum calcium levels and independence from active vitamin D and oral calcium therapy.

Also Read: AstraZeneca’s Imfinzi-Based Regimen Shows Improved Event-Free Survival In Early-Stage Gastric Cancer Patients

HypoPT is a rare endocrine disease caused by a deficiency of PTH and is characterized by impaired regulation of calcium and phosphate levels in the blood. Eneboparatide was well tolerated.

After the 24-week randomized treatment period, all patients receive eneboparatide in the ongoing long-term extension until 52 weeks. Full efficacy and safety data will be analyzed at 52 weeks.

Concurrently, AstraZeneca and Alteogen entered into an exclusive license agreement for ALT-B4, a hyaluronidase utilizing Hybrozyme platform technology.

Under the terms of the agreement, AstraZeneca will acquire worldwide rights to use ALT-B4 to develop and commercialize subcutaneous formulations of several oncology assets.

Alteogen will be responsible for the clinical and commercial supply of ALT-B4 to AstraZeneca.

AstraZeneca will pay Alteogen an upfront payment and additional payments upon achieving specific development, regulatory, and sales-related milestones. Additionally, Alteogen will receive royalties on the sales of the commercialized products.

On Monday, the European Union approved AstraZeneca’s Imfinzi (durvalumab) as monotherapy for adults with limited-stage small cell lung cancer whose disease has not progressed following platinum-based chemoradiation therapy.

The approval is based on results from the ADRIATIC Phase 3 trial.

The trial showed that Imfinzi reduced the risk of death by 27% compared to placebo.

The estimated median overall survival was 55.9 months for Imfinzi versus 33.4 months for placebo. An estimated 57% of patients treated with Imfinzi were alive at three years compared to 48% for placebo.

Imfinzi also reduced the risk of disease progression or death by 24% versus placebo.

The median progression-free survival (PFS) was 16.6 months for Imfinzi versus 9.2 months for placebo. An estimated 46% of patients treated with Imfinzi had not experienced disease progression at two years compared to 34% for placebo.

Earlier on Monday, AstraZeneca agreed to acquire cell therapy focused-EsoBiotec SA for up to $1 billion.

Price Action: At the last check on Monday, AZN stock was down 1.04% to $76.78 during the premarket session.

Read Next:

  • Hain Celestial Valuation Is Low Versus Historical Levels, But Analyst Remains Neutral – Here’s Why

Image by Robert Way via Shutterstock

Continue Reading...

Popular

IRS whistleblower on Hunter Biden is out as acting commissioner just days after getting the job

WASHINGTON (AP) — Just days after to acting IRS commissioner, the whistleblower who testified publicly about investigations into Hunter Biden’s taxes is out of the job, according to three people familiar with the decision.

Rep. Marjorie Taylor Greene bought stocks hit hard by Trump tariffs during the market meltdown

NEW YORK (AP) — Give Marjorie Taylor Greene credit where it’s due: As stocks tanked on tariff fears, she showed her faith in the president not just with words but dollar bills.

Elon's Biggest Secret Could Save Your Retirement - Ad

From a near-fatal car crash to surviving deadly malaria, Musk's fearless drive built Tesla, SpaceX, and Starlink. Now, he's warning America--and smart investors are listening. Discover the Trump IRS Loophole to protect your IRA & 401(k).

Prince Harry appeals the loss of his UK security detail

LONDON (AP) — wants his British security detail restored and is taking his case to an appeals court.

Trump meets with the House GOP as his 'big' bill of tax breaks and spending cuts teeters

WASHINGTON (AP) — found himself in a familiar jam on Tuesday: Conservative Republican holdouts are stalling action on "big” bill of tax breaks and spending reductions, refusing to accept approved over the weekend because it doesn't cut enough.

Top Choice for Tech-Savvy Investors - Ad

Exploring the next wave of electric aviation stocks? This company is leading the charge with its innovative approach to electrification and strong industry ties.

PHOTO ESSAY: In a Greek island monastery, a monk has kept together faith and community for 50 years

AMORGOS, Greece (AP) — For more than 50 years, Spyridon Denaxas — or Father Spyridon, as he’s affectionately called — has prayed, worked and welcomed the faithful in a millennium-old monastery carved into a seaside cliff on the Greek island of Amorgos.

Trump hits the golf course as stock market continues to slide from his tariff plans

WEST PALM BEACH, Fla. (AP) — Two days after sending the global economy reeling by on foreign imports, President insisted his trade policies will “NEVER CHANGE” as he remained ensconced in a bubble of wealth and power in Florida.

Out of 23,281 Stocks... This Is the Only One - Ad

Out of 23,281 stocks, one stands out - wildly profitable, deeply undervalued. It generates $1B+ more cash than AMD, yet trades 20x cheaper. Backed by Trump and partnered with a top AI firm, this could be the stock to own now.

US egg giant Cal-Maine says government is investigating price increases

Shares of Cal-Maine Foods, the largest U.S. egg producer, fell in after-hours trading Tuesday after the company acknowledged it is being investigated by the antitrust division of the U.S. Department of Justice.

Putting Your Name on This List Could Hand You $1,270 on Friday - Ad

URGENT: On Tuesday, a simple set of instructions will be sent out to an elite group of investors. The folks in this group will have the opportunity to place a 10-minute trade that could double their money by Friday. Consider this your invitation to join them. The next trade is just days away.

Expect more fake eggs made of colored marshmallows or even potatoes on this year's Easter spread

MISSION, Kan. (AP) — With egg prices high, the internet has offered up a host of alternatives, with crafters painting rocks and influencers dyeing everything from marshmallows to potatoes.

Trump advisers say 50-plus countries have reached out for tariff talks with White House

FORT LAUDERDALE, Fla. (AP) — Top administration officials said Sunday that more than targeted by President Donald Trump's have reached out to begin negotiations over the sweeping import taxes that have sent , raised fears of a recession and upended the .

Maverick Trader Reveals 97% Accurate System - Ad

This man's simple strategy makes money in any market...With a 97% accuracy at hitting winners over the past 8 years!

Trump's China tariffs swing a sledgehammer at importers and cheap goods

WASHINGTON (AP) — Rick Woldenberg thought he had come up with a sure-fire plan to protect his Chicago-area educational toy company from President Donald Trump’s on Chinese imports.

Palantir Goes Bullish After NATO's AI Buy: Is This The Future Of War, Wall Street?

Palantir's stock jumps 9% after NATO acquires its AI-enabled system, showing its dominance in data and potential for growth.

Brace Yourself for Jeff Bezos' "Amazon Helios" - Ad

Amazon delivers 20 million packages a day... powers some of the most popular websites... delivers medication to half of the U.S. population... and even produces award-winning films and TV shows. But a Wall Street legend -- twice featured on 60 Minutes -- predicts that "Amazon Helios" will be bigger than all of those... COMBINED.

$74 Billion Wiped Out Since Tariff Declaration - See How Much The Billionaires Lost

In a significant market downturn since President Trump announced new tariffs worldwide, the world's wealthiest individuals have seen their fortunes shrink by $74 billion.

As Trump considers auto tariffs pause, parts exemptions could be key for US industry

DETROIT (AP) — President Donald Trump hinted that he might temporarily relieve the auto industry from “permanent” on the business. The president didn't specify how long the potential pause would be or what it would entail, but is awaiting how rules might change on 25% tariffs based on U.S. parts, if duties remain on assembled vehicles.

The Best Electric Aviation Stock to Keep an Eye On - Ad

Looking for the next big EV opportunity? The market is expanding rapidly, and one stock is standing out with its innovative approach and strong industry partnerships. Find out more about this potential game-changer.

What to know about the tensions between Iran and the US before their second round of talks

DUBAI, United Arab Emirates (AP) — and the United States will hold talks Saturday in Rome, their second round of negotiations over Tehran’s rapidly advancing nuclear program.

Apple Tops Global Smartphone Sales With 19% Share, Boosted By iPhone 16e, Emerging Market Growth

Apple tops global smartphone sales in Q1 with 19% share, helped by iPhone 16e launch and growth in emerging markets. Samsung follows with 18% share. Tariffs may impact market decline in 2025.

World Economic Forum: "Arguably the Most Exciting Human Discovery Since Fire" - Ad

Sam Altman, Bill Gates, and Mark Zuckerberg are all investing vast sums of money into a radical technology. According to Bloomberg, this could become 10 times bigger than AI, quantum computing, electric vehicles, cryptocurrencies, and robotics combined. And one stock is at the center of it all.

Recession? Not So Fast, Says IMF — Even After Trump Tariff Chaos

The IMF has expressed concern over escalating trade tensions sparked by new U.S. tariffs but emphasized that a global recession is not on the horizon.

Trump considers pausing his auto tariffs as the world economy endures whiplash

WASHINGTON (AP) — President Donald Trump on Monday suggested that he might temporarily exempt the auto industry from on the sector, to give carmakers time to adjust their supply chains.

Biggest Dividend Payout in U.S. History: $1 Trillion up for Grabs! - Ad

Trump just launched a $1 trillion National Investment Fund to replace income taxes and send direct payouts to Americans. You could claim up to $21,307--before the first public checks go out. This is historic. Act now to be first in line.

Dan Ives Cuts Tesla Target To $315, Slashes Apple By 23% Amid Tariff Fallout, Warns Elon Musk-Led EV Maker Faces 'Darker Days' Ahead

Wedbush Securities analyst Dan Ives has lowered his Tesla Inc. price target to $315 from $550 while maintaining an "outperform" rating, citing growing concerns about the electric vehicle maker's brand perception and softening demand.

Cloudflare Acquires Outerbase To Streamline AI App Development, 'Our Goal Is To Make It Easy And Accessible For Any Developer'

The move integrates Outerbase's user-friendly database tools with Cloudflare Workers, Durable Objects and the D1 database, helping developers manage backend data without deep SQL knowledge.

No.1 Opportunity for 2025 [Take Action Now!] - Ad

Starlink's potential IPO Could Be the Biggest in History--Silicon Valley insider James Altucher has uncovered a way to profit BEFORE the IPO--with as little as $50. Musk's $180B giant is set to launch--will you miss out? Claim your spot before it's too late.

Company plans to restart Keystone Pipeline after oil spill in rural North Dakota

BISMARCK, N.D. (AP) — The operator of the said it planned to restart the system Monday after a last week shut down the line.

White House threatens Colombia over regulations affecting US auto exports

BOGOTA, Colombia (AP) — The White House is urging Colombia to halt the implementation of new auto safety regulations that could jeopardize American car exports to Colombia, as both nations prepare to discuss tariffs recently imposed on Colombian products including coffee, avocados, flowers and oil.

New Study: 50 Stocks Will Crash While 7 MAGA Stocks Will Soar - Ad

If you own any of these stocks -- directly or through mutual funds -- I want to encourage you to sell them before April 30th. I've compiled all 50 companies in my "MAGA Blacklist" report. Your retirement could depend on seeing this list.

Ripple's Crypto Warning, Circle's IPO Ambitions, And Bitcoin's Anticipated Surge: This Week In Crypto

The weekend saw major developments in the cryptocurrency world, including Ripple's concerns over the UK's crypto regulations, Circle's plans for a $5 billion IPO, Anthony Pompliano's praise for Trump's tariffs as a catalyst for crypto, and expectations of a Bitcoin price surge following potential monetary easing by the Fed.

Bitcoin 11% Away From Falling Below Strategy's Average Buying Price, But Michael Saylor's Confidence In Apex Crypto Remains Intact

Strategy Inc. (NASDAQ:MSTR) risked incurring unrealized losses on its Bitcoin (CRYPTO: BTC) purchases, yet co-founder Michael Saylor remains bullish on the apex cryptocurrency.

The Most Important "AI Stock" You've Never Heard Of - Ad

The AI revolution is moving faster than anyone expected. But what no one is talking about is the one company AI simply can't exist without. It may be the single most important AI investment, yet most people don't even know its name. For now. The moment Wall Street catches on, this $20 stock could explode.

Ex-Abercrombie CEO has dementia and is unfit for sex trafficking trial, prosecutors and defense say

NEW YORK (AP) — The former CEO of Abercrombie & Fitch is suffering from dementia and isn't competent to , according to prosecutors and his lawyers.

What's Going On With Starwood Property Trust Stock On Friday?

Starwood Property Trust affiliate Starwood Capital acquires $800M Texas housing portfolio from Hines.

Elon Musk Drops Stunning Bombshell? - Ad

Behind closed doors, Musk revealed a game-changing breakthrough technology that could shake the tech world & crush major companies. Why is no one talking about it? Luckily, we had a man on the inside - watch now to see the details & how to profit!

White House Updates Status On Mistaken Deportation To El Salvador

President Trump's administration has disclosed a wellness report for a Maryland man who was erroneously deported to El Salvador.

Trending Now

Information, charts or examples are for illustration and educational purposes only and not for individualized investment management This message contains commercial elements, such as advertising. We only send these offers to those who have opted in to our newsletter. Past performance is not indicative of future results. For these reasons we strongly suggest trading in a DEMO/Simulated account. The information provided by us is for educational and informational purposes only. We make no representations or warranties concerning the products, practices or procedures of any company or entity mentioned or recommended and have not determined if the statements and opinions of the advertiser are accurate, correct or truthful. If you use, act upon or make decisions in reliance on information contained or any external source linked within it, you do so at your own peril and agree to hold us, our officers, directors, shareholders, affiliates and agents without fault.

Copyright activatrade.ca
Privacy Policy | Terms of Service